| Time | Network | Show | Viewers | 18-49 |
|---|---|---|---|---|
| 8PM | NBC | NFL Opening Kickoff 2010 | 15.51 | 5.6/18 |
| CBS | Big Brother 12 | 8.18 | 2.7/9 | |
| ABC | Wipeout (R) | 5.15 | 1.4/4 | |
| FOX | Bones (R) | 4.36 | 1.0/3 | |
| CW | The Vampire Diaries | 3.27 | 1.6/5 | |
| 8:30PM | NBC | NFL Football: Vikings vs Saints | 22.56 | 8.2/23 |
| 9PM | NBC | NFL Football: Vikings vs Saints | 26.90 | 10/27 |
| CBS | CBS (R) | 6.01 | 1.2/3 | |
| ABC | Rookie Blue | 5.01 | 1.3/3 | |
| CW | Nikita (Premiere) | 3.60 | 1.4/4 | |
| FOX | Fringe (R) | 2.63 | 0.8/2 | |
| 10PM | NBC | NFL Football: Vikings vs Saints | 23.13 | 9.5/25 |
| CBS | The Mentalist (R) | 6.60 | 1.2/3 | |
| ABC | Rookie Blue | 4.69 | 1.1/3 |